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pooled whole genome and whole exome sequence database  (Broad Institute Inc)

 
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    Structured Review

    Broad Institute Inc pooled whole genome and whole exome sequence database
    Structural mapping of 21 pathogenic (magenta) and 261 uncategorized (yellow) protein variants to the human MUTYH model [80], which lacks the unstructured 81 amino acid N-terminus region. The pathogenic cancer-associated MAP variant locations (emphasized with side chains shown) are from LOVD database [27,28]. Yellow regions denote MUTYH missense variants detected in whole genome or whole <t>exome</t> sequencing in over 131,000 individuals from clinical and control populations (gnomAD MUTYH entry: http://gnomad.broadinstitute.org/gene/ENSG00000132781; ref. 32). <t>Wild-type</t> <t>sequence:</t> green; Interdomain connector (IDC): black; Zinc lynchpin motif: red/blue; Iron-sulfur cluster: orange.
    Pooled Whole Genome And Whole Exome Sequence Database, supplied by Broad Institute Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/pooled+whole+genome+and+whole+exome+sequence+database/pmc06812671-74-11-1?v=Broad+Institute+Inc
    Average 90 stars, based on 1 article reviews
    pooled whole genome and whole exome sequence database - by Bioz Stars, 2026-07
    90/100 stars

    Images

    1) Product Images from "When you’re strange: Unusual features of the MUTYH glycosylase and implications in cancer"

    Article Title: When you’re strange: Unusual features of the MUTYH glycosylase and implications in cancer

    Journal: DNA repair

    doi: 10.1016/j.dnarep.2019.05.005

    Structural mapping of 21 pathogenic (magenta) and 261 uncategorized (yellow) protein variants to the human MUTYH model [80], which lacks the unstructured 81 amino acid N-terminus region. The pathogenic cancer-associated MAP variant locations (emphasized with side chains shown) are from LOVD database [27,28]. Yellow regions denote MUTYH missense variants detected in whole genome or whole exome sequencing in over 131,000 individuals from clinical and control populations (gnomAD MUTYH entry: http://gnomad.broadinstitute.org/gene/ENSG00000132781; ref. 32). Wild-type sequence: green; Interdomain connector (IDC): black; Zinc lynchpin motif: red/blue; Iron-sulfur cluster: orange.
    Figure Legend Snippet: Structural mapping of 21 pathogenic (magenta) and 261 uncategorized (yellow) protein variants to the human MUTYH model [80], which lacks the unstructured 81 amino acid N-terminus region. The pathogenic cancer-associated MAP variant locations (emphasized with side chains shown) are from LOVD database [27,28]. Yellow regions denote MUTYH missense variants detected in whole genome or whole exome sequencing in over 131,000 individuals from clinical and control populations (gnomAD MUTYH entry: http://gnomad.broadinstitute.org/gene/ENSG00000132781; ref. 32). Wild-type sequence: green; Interdomain connector (IDC): black; Zinc lynchpin motif: red/blue; Iron-sulfur cluster: orange.

    Techniques Used: Variant Assay, Sequencing, Control



    Similar Products

    pooled whole genome and whole exome sequence database  (Broad Institute Inc)
    90
    Broad Institute Inc pooled whole genome and whole exome sequence database
    Structural mapping of 21 pathogenic (magenta) and 261 uncategorized (yellow) protein variants to the human MUTYH model [80], which lacks the unstructured 81 amino acid N-terminus region. The pathogenic cancer-associated MAP variant locations (emphasized with side chains shown) are from LOVD database [27,28]. Yellow regions denote MUTYH missense variants detected in whole genome or whole <t>exome</t> sequencing in over 131,000 individuals from clinical and control populations (gnomAD MUTYH entry: http://gnomad.broadinstitute.org/gene/ENSG00000132781; ref. 32). <t>Wild-type</t> <t>sequence:</t> green; Interdomain connector (IDC): black; Zinc lynchpin motif: red/blue; Iron-sulfur cluster: orange.
    Pooled Whole Genome And Whole Exome Sequence Database, supplied by Broad Institute Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/pooled+whole+genome+and+whole+exome+sequence+database/pmc06812671-74-11-1?v=Broad+Institute+Inc
    Average 90 stars, based on 1 article reviews
    pooled whole genome and whole exome sequence database - by Bioz Stars, 2026-07
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    Structural mapping of 21 pathogenic (magenta) and 261 uncategorized (yellow) protein variants to the human MUTYH model [80], which lacks the unstructured 81 amino acid N-terminus region. The pathogenic cancer-associated MAP variant locations (emphasized with side chains shown) are from LOVD database [27,28]. Yellow regions denote MUTYH missense variants detected in whole genome or whole exome sequencing in over 131,000 individuals from clinical and control populations (gnomAD MUTYH entry: http://gnomad.broadinstitute.org/gene/ENSG00000132781; ref. 32). Wild-type sequence: green; Interdomain connector (IDC): black; Zinc lynchpin motif: red/blue; Iron-sulfur cluster: orange.

    Journal: DNA repair

    Article Title: When you’re strange: Unusual features of the MUTYH glycosylase and implications in cancer

    doi: 10.1016/j.dnarep.2019.05.005

    Figure Lengend Snippet: Structural mapping of 21 pathogenic (magenta) and 261 uncategorized (yellow) protein variants to the human MUTYH model [80], which lacks the unstructured 81 amino acid N-terminus region. The pathogenic cancer-associated MAP variant locations (emphasized with side chains shown) are from LOVD database [27,28]. Yellow regions denote MUTYH missense variants detected in whole genome or whole exome sequencing in over 131,000 individuals from clinical and control populations (gnomAD MUTYH entry: http://gnomad.broadinstitute.org/gene/ENSG00000132781; ref. 32). Wild-type sequence: green; Interdomain connector (IDC): black; Zinc lynchpin motif: red/blue; Iron-sulfur cluster: orange.

    Article Snippet: The Broad Institute has made available a pooled whole genome and whole exome sequence database in clinical and control populations from over 131,000 individuals ( http://gnomad.broadinstitute.org/about ; Ref. [ 32 ]).

    Techniques: Variant Assay, Sequencing, Control